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She was 68 years old.
According to Variety, Zazula died after battling cancer.
"The world of music owes a debt of gratitude to Marsha Zazula, who along with her husband Jon gave birth to some of the most musically significant artists," Megaforce said in a statement.
"Marsha was one of a kind and taught the world to be fiercely independent. Megaforce and our artists will never forget her. In our hearts she will always be a guiding force. R.I.P."
Zazula and her husband Jon in 1982 co-founded Megaforce Records, which released the first music albums for Anthrax, Metallica, Kiss guitarist Ace Frehley and more.
The Zazulas frequented metal concerts and are well-known in the music arena.
Jon was the owner of New Jersey's Rock'n Roll Heaven record store in East Brunswick.
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